Selected Publications

  • Szabadkai I, Torka R, Garamvölgyi R, Baska F, Gyulavári P, Boros S, Illyés E, Choidas A, Ullrich A and Örfi L (2018): 
      Discovery of N-[4-(Quinolin-4-aloxy)phenyl]benzenesulfonamides as novel AXL kinase inhibitors
     J Med Chem. doi: 10.1021/acs.jmedchem.8b00672
  • Baumann C, Ullrich A and Torka R (2017): 
      GAS6-expressing and self-sustaining cancer cells in 3D spheroids activate the PDK-RSK-mTOR pathway for survival and drug resistance
     Mol Oncol. 
  • Onken J, Vajkoczy P, Torka R, Hempt C, Patsouris V, Heppner FL and Radke J (2017): 
      Phospho-AXL is widely expressed in glioblastoma and associated with significant shorter overall survival
     Oncotarget. 8(31):50403-50414
  • Orfi Z, Waczek F, Baska F, Szabadkai I, Torka R, Hartmann J, Orfi L and Ullrich A (2017): 
      Novel members of quinoline compound family enhance insulin secretion in RIN-5AH beta cells and in rat pancreatic islet microtissue. 
     Sci Rep. 7:44073
  • Onken J, Torka R, Korsing S, Radke J, Krementeskaia I, Nieminen M, Bai X, Ullrich A, Heppner F and Vajkoczy P (2016): 
      Inhibiting receptor tyrosine kinase AXL with small molecule inhibitor BMS-777607 reduces glioblastoma growth, migration, and invasion in vitro and in vivo. 
     Oncotarget. 7(9):9876-89
  • Pénzes K, Baumann C, Szabadkai I, Orfi L, Kéri G, Ullrich A and Torka R (2014): 
      Combined inhibition of AXL, Lyn and p130Cas kinases block migration of triple negative breast cancer cells
     Cancer Biol Ther. 15(11):1571-82
  • Szokol B, Gyulavári P, Kurkó I, Baska F, Szántai-Kis C, Greff Z, Orfi Z, Peták I, Pénzes K, Torka R, Ullrich A, Orfi L, Vántus T and Kéri G (2014): 
      Discovery and Biological Evaluation of Novel Dual EGFR/c-Met Inhibitors
     ACS Med Chem Lett. 5(4):298-303
  • Torka R, Pénzes K, Gusenbauer S, Baumann C, Szabadkai I, Őrfi L, Kéri G and Ullrich A (2014): 
      Activation of HER3 interferes with antitumor effects of Axl receptor tyrosine kinase inhibitors: suggestion of combination therapy
     Neoplasia. 16(4):301-18
  • Baska F, Szabadkai I, Sipos A, Breza N, Szántai-Kis C, Kékesi L, Garamvölgyi R, Nemes Z, Baska F, Neumann L, Torka R, Ullrich A, Kéri G and Orfi L (2014): 
      Pharmacophore and binding analysis of known and novel B-RAF kinase inhibitors
     Curr Med Chem. 21(17):1938-55
  • Paolino M, Choidas A, Wallner S, Pranjic B, Uribesalgo I, Loeser S, Jamieson AM, Langdon WY, Ikeda F, Fededa JP, Cronin SJ, Nitsch R, Schultz-Fademrecht C, Eickhoff J, Menninger S, Unger A, Torka R, Gruber T, Hinterleitner R, Baier G, Wolf D, Ullrich A, Klebl BM and Penninger JM (2014): 
      The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells
     Nature. 507(7493):508-12
  • Lorenz K, Grashoff C, Torka R, Sakai T, Langbein L, Bloch W, Aumailley M and Fässler R (2007): 
      Integrin-linked kinase is required for epidermal and hair follicle morphogenesis
     J Cell Biol. 177(3):501-13
  • Torka R, Thuma F, Herzog V and Kirfel G (2006): 
      ROCK signaling mediates the adoption of different modes of migration and invasion in human mammary epithelial tumor cells
     Exp Cell Res. 312(19):3857-71
  • Bollmann R, Méhes G, Torka R, Speich N, Schmitt C and Bollmann M (2003): 
      Determination of features indicating progression in atypical squamous cells with undetermined significance: human papillomavirus typing and DNA ploidy analysis from liquid-based cytologic samples
     Cancer. 99(2):113-7
  • Bollmann R, Méhes G, Torka R, Speich N, Schmitt C and Bollmann M (2003): 
      Human papillomavirus typing and DNA ploidy determination of squamous intraepithelial lesions in liquid-based cytologic samples
     Cancer. 99(1), 57-62
  • Bollmann R, Torka R, Schmitz J, Bollmann M and Méhes G (2002): 
      Determination of ploidy and steroid receptor status in breast cancer by laser scanning cytometry
     Cytometry. 50(4), 210-5


Prof. Dr. Guido Posern

Abt. Signaltransduktion: 
Leiter:    Robert Torka 
Telefon: (0345) 557-3820 
Email:     Email

Institut für Physiologische Chemie
Hollystrasse 1
06114 Halle (Saale)

Assistenz der Institutsleitung:
Ines Knipping
Telefon: (0345) 557-3812 
Fax:        (0345) 557-3811
Email:    Email