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Selected Publications

Szabadkai I, Torka R, Garamvölgyi R, Baska F, Gyulavári P, Boros S, Illyés E, 

Choidas A, Ullrich A, Őrfi L. 

Discovery of N-[4-(Quinolin-4-yloxy)phenyl]benzenesulfonamides as Novel AXL Kinase Inhibitors.

J Med Chem. 2018 Jul 9. 

 

Onken J, Vajkoczy P, Torka R, Hempt C, Patsouris V, Heppner FL, Radke J.

Phospho-AXL is widely expressed in glioblastoma and associated with significant

shorter overall survival. Oncotarget. 2017 Jun 13;8(31):50403-50414. 

 

Baumann C, Ullrich A, Torka R

GAS6-expressing and self-sustaining cancer cells in 3D spheroids activate the PDK-RSK-mTOR pathway for survival and drug resistance. 

Mol Oncol. 2017 Oct;11(10):1430-1447.

 

Onken J, Torka R, Korsing S, Radke J, Krementeskaia I, Nieminen M, Bai X, Ullrich A, Heppner F, Vajkoczy P.

Inhibiting receptor tyrosine kinase AXL with small molecule inhibitor BMS-777607 reduces glioblastoma growth, migration, and invasion in vitro and in vivo. 

Oncotarget. 2016 Mar 1;7(9):9876-89. 

 

Pénzes K, Baumann C, Szabadkai I, Orfi L, Kéri G, Ullrich A, Torka R

Combined inhibition of AXL, Lyn and p130Cas kinases block migration of triple negative breast cancer cells.

Cancer Biol Ther. 2014;15(11):1571-82. 

 

Szokol B, Gyulavári P, Kurkó I, Baska F, Szántai-Kis C, Greff Z, Orfi Z, Peták I, Pénzes K, Torka R, Ullrich A, Orfi L, Vántus T, Kéri G.

Discovery andBiological Evaluation of Novel Dual EGFR/c-Met Inhibitors. 

ACS Med Chem Lett. 2014 Jan 30;5(4):298-303. 

 

Torka R, Pénzes K, Gusenbauer S, Baumann C, Szabadkai I, Őrfi L, Kéri G, Ullrich A.

 Activation of HER3 interferes with antitumor effects of Axl receptor tyrosine kinase inhibitors: suggestion of combination therapy. 

Neoplasia. 2014 Apr;16(4):301-18.

 

Paolino M, Choidas A, Wallner S, Pranjic B, Uribesalgo I, Loeser S, Jamieson AM, Langdon WY, Ikeda F, Fededa JP, Cronin SJ, Nitsch R, Schultz-Fademrecht C, Eickhoff J, Menninger S, Unger A, Torka R, Gruber T, Hinterleitner R, Baier G, Wolf D, Ullrich A, Klebl BM, Penninger JM. 

The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells. 

Nature. 2014 Mar27;507(7493):508-12. 

 

Lorenz K, Grashoff C, Torka R, Sakai T, Langbein L, Bloch W, Aumailley M, Fässler R. 

Integrin-linked kinase is required for epidermal and hair follicle morphogenesis. 

J Cell Biol. 2007 May 7;177(3):501-13. 

 

Torka R, Thuma F, Herzog V, Kirfel G. 

ROCK signaling mediates the adoption of different modes of migration and invasion in human mammary epithelial tumor cells. 

Exp Cell Res. 2006 Nov 15;312(19):3857-71. 

 

Bollmann R, Méhes G, Torka R, Speich N, Schmitt C, Bollmann M. 

Determination of features indicating progression in atypical squamous cells with undetermined significance: human papillomavirus typing and DNA ploidy analysis fromliquid-based cytologic samples. 

Cancer. 2003 Apr 25;99(2):113-7. 

 

Bollmann R, Méhes G, Torka R, Speich N, Schmitt C, Bollmann M. 

Human papillomavirus typing and DNA ploidy determination of squamous intraepithelial lesions in liquid-based cytologic samples. 

Cancer. 2003 Feb 25;99(1):57-62.  

 

Bollmann R, Torka R, Schmitz J, Bollmann M, Méhes G. 

Determination of ploidy and steroid receptor status in breast cancer by laser scanning cytometry.

Cytometry. 2002 Aug 15;50(4):210-5.

 

 

Direktor:
Prof. Dr. Guido Posern

AG Signaltransduktion: 
Leiter:    Robert Torka 
Telefon: (0345) 557-3820 
Email:     Email

Hausanschrift:
Institut für Physiologische Chemie
Hollystrasse 1
06114 Halle (Saale)

Assistenz der Institutsleitung:
Ines Knipping
Telefon: (0345) 557-3812 
Fax:        (0345) 557-3811
Email:    Email