Selected Publications

  • Liu H and Pfirrmann T (2019):
     The GID-complex: an emerging player in the ubiquitin ligase league.
    Biol Chem. doi:10.1515/hsz-2019-0139
  • Kraya T, Quandt D, Pfirrmann T, Kindermann A, Lampe L, Schroeter ML, Kohlhase J, Stoevesandt D, Hoffmann K and Villavicencio-Lorini P (2019):
     Functional characterization of a novel CSF1R mutation causing hereditary diffuse leukoencephalopathy with spheroids.
    Mol Genet Genomic Med. 6:e595; doi:10.1002/mgg3.595
  • Martins A, Pfirrmann T, Heessen S, Sundqvist G, Bulone V, Andréasson C and Ljunggdahl PO (2018):
     Ssy5 is a signaling serine protease that exhibits atypical biogenesis and marked S1 specifity.
    J Biol Chem. 293(22):8362-8378
  • Klaus A, Pfirrmann T and Glomb MA (2017):
     Transketolase A from E.coli Significantly Suppresses Protein Glycation by Glycoaldehyde and Glyoxal in Vitro.
    J Agric Food Chem. 65(37):8196-8202
  • Jennek S, Mittag S, Reiche J, Westphal JK, Seelk S, Dörfel MJ, Pfirrmann T, Friedrich K, Schütz A, Heinemann U and Huber O (2017):
     Tricellulin is a target of the ubiquitin ligase Itch.
    Ann N Y Acad Sci. 1397(1):157-168
  • Pfirrmann T, Jandt E, Ranft S, Lokapally A, Neuhaus H, Perron M and Hollemann T (2016):
     Hedgehog-dependent E3-ligase Midline1 regulates ubiquitin-mediated proteasomal degradation of Pax6 during visual system development.
    Proc Natl Acad Sci U S A. 113(36):10103-8
  • Pfirrmann T, Villavicencio-Lorini P, Subudhi AK, Menssen R, Wolf DH and Hollemann T (2015):
     RMND5 from Xenopus laevis is an E3 ubiquitin-ligase and functions in early embryonic forebrain development.
    PLoS One. 10(3):e0120342
  • Pfirrmann T, Emmerich D, Ruokonen P, Quandt D, Buchen R, Fischer-Zirnsak B, Hecht J, Krawitz P, Meyer P, Klopocki E, Stricker S, Lausch E, Seliger B, Hollemann T, Reinhard T, Auw-Haedrich C, Zabel B, Hoffmann K and Villavicencio-Lorini P (2015):
     Molecular mechanism of CHRDL1-mediated X-linked megalocornea in humans and in Xenopus model.
    Hum Mol Genet. 24(11):3119-32
  • Pfirrmann T, Lokapally A, Andreasson C, Ljungdahl P and Hollemann T (2013):
     SOMA: a single oligonucleotide mutagenesis and cloning approach.
    PloS one. 8(6):e64870
  • Zhao B, Velasco K, Sompallae R, Pfirrmann T, Masucci MG and Lindsten K (2012):
     The ubiquitin specific protease-4 (USP4) interacts with the S9/Rpn6 subunit of the proteasome.
    Biochemical and biophysical research communications. 427(3):490-6
  • Omnus DJ, Pfirrmann T, Andreasson C and Ljungdahl PO (2011):
     A phosphodegron controls nutrient-induced proteasomal activation of the signaling protease Ssy5.
    Molecular biology of the cell. 22, 2754-2765
  • Braun B, Pfirrmann T, Menssen R, Hofmann K, Scheel H and Wolf DH (2011):
     Gid9, a second RING finger protein contributes to the ubiquitin ligase activity of the Gid complex required for catabolite degradation.
    FEBS letters. 585:3856-3861
  • Basseres E, Coppotelli G, Pfirrmann T, Andersen JB, Masucci M and Frisan T (2010):
     The ubiquitin C-terminal hydrolase UCH-L1 promotes bacterial invasion by altering the dynamics of the actin cytoskeleton.
    Cellular microbiology. 12:1622-1633
  • Pfirrmann T, Heessen S, Omnus DJ, Andreasson C and Ljungdahl PO (2010):
     The prodomain of Ssy5 protease controls receptor-activated proteolysis of transcription factor Stp1.
    Molecular and cellular biology. 30:3299-3309
  • Rolen U, Freda E, Xie J, Pfirrmann T, Frisan T and Masucci MG (2009):
     The ubiquitin C-terminal hydrolase UCH-L1 regulates B-cell proliferation and integrin activation.
    Journal of cellular and molecular medicine. 13:1666-1678
  • Santt O, Pfirrmann T, Braun B, Juretschke J, Kimmig P, Scheel H, Hofmann K, Thumm M and Wolf DH (2008):
     The yeast GID complex, a novel ubiquitin ligase (E3) involved in the regulation of carbohydrate metabolism.
    Molecular biology of the cell. 19:3323-3333
  • Eisele F, Braun B, Pfirrmann T and Wolf DH (2006):
     Mutants of the deubiquitinating enzyme Ubp14 decipher pathway diversity of ubiquitin-proteasome linked protein degradation.
    Biochemical and biophysical research communications. 350:329-333




Prof. Dr. Guido Posern

AG Ubiquitination: 
Leiter:    Thorsten Pfirrmann 
Telefon: (0345) 557-3802 
Fax:        (0345) 557-3804 
Email:     Email

Institut für Physiologische Chemie
Hollystrasse 1
06114 Halle (Saale)

Assistenz der Institutsleitung:
Ines Knipping
Telefon: (0345) 557-3812 
Fax:        (0345) 557-3811
Email:    Email